There are two ways to mark a person as a Subject on the People List sub-tab:
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Bulk assignment: In the grid, select the individual(s) you want to mark as Subjects by clicking the checkbox(es) on the left. Then click the "Make Subject" button. This option allows you to assign multiple individuals as Subjects at once.
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Individual assignment: In the grid, click "Modify" for the individual. Then select the "Subject?"check-box and click "Save." This option allows you to assign one person as a Subject at a time.